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For patients with severe renal insufficiency (CrCl less than 30 mL/min, approximately corresponding to serum creatinine levels of greater than 3.0 mg/dL in men and greater than 2.5 mg/dL in women) or with end-stage renal disease (ESRD) requiring hemodialysis or peritoneal dialysis, the dose of Januvia is 25 mg once daily

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They may boost GLP-1 secretion

More recently, the regulators pursuit of supplement business BIOV8 helped send the company into liquidation, with $1.42 million in debt, and a messy falling out between its two co-founders that played out before the Federal Court